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2-phenylbenzo[f][1,3]benzoxazole-4,9-dione

CAS號	63388-44-3
規格	5mg10mg	純度	98%
貨號	HY-15757	貨期	3天
品牌	Medchemexpress	庫存	需咨詢
規格	5mg10mg
純度	98%
貨號	HY-15757
貨期	3天
品牌	Medchemexpress
庫存	---
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參考價：￥2167.00 元/5mg

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貨號	品牌	純度	規格	參考價	貨期
HY-15757	Medchemexpress	98%	5mg10mg	￥2167.00元/5mg	3天

產品詳情

詳細信息(中文)：
SJB2-043是C527的類似物，是新型的泛素特異蛋白酶USP1抑制劑，IC50為544nM。

詳細信息(英文)：
產品描述：SJB2-043SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor. _x000D_ IC50 Value: 0.544 uM (USP1) [1]_x000D_ Target: USP1_x000D_ Cells were treated with SJB2-043 for 24 hrs and cell extracts were incubated with HA-Ub-VS, followed by immunoblotting with anti-USP1 or anti-HA antibodies. Consistent with our previous studies and the most recent studies by Piatkov et al (24, 31, 33), USP1 in the untreated cells was detected on western blot as a doublet; full length USP1 and an auto-cleaved USP1 with only N-terminus. The Ub-USP1 conjugates were generated in the untreated cell lysates and were detected by an increase in molecular weight of USP1. However, the formation of the Ub-USP1 conjugate was inhibited by the addition of SJB2-043. Ub-aldehyde, a potent known nonspecific DUB inhibitor, caused a complete loss of USP1-Ub-VS conjugates in this competition assay. SJB2-043 inhibited the Ub-VS labeling of a limited number of endogenous DUB enzymes. In 公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設有歐洲區子公司和亞洲區總代理，營銷網點遍及全球20多個國家地區。MCE經過多年努力已成為全球生物活性小分子領域的一流供應商，產品涵蓋癌癥、神經科學、抗感染、表觀遺傳學等20個熱門研究領域，PI3K、MAPK等近千個細分靶點，超過4000個活性小分子化合物現貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時提供從毫克到千克的專業定制合成服務。 MCE 對每批產品都進行嚴格的LCMS和NMR檢驗，其產品已被全球近萬名客戶廣泛使用并發表大量文章、專利； MCE 定期增加各領域熱門抑制劑、激動劑，不斷擴增已有化合物庫，以滿足最新的科研需求；數千種產品在上海有充足備貨，24-48小時內送達客戶；大量產品提供免費試用裝；已為全球多個知名企業、院校構建各種定制型化合物庫。產品鏈接：www.medchemexpress.cn/sjb2-043.html