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3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-1,2-oxazole-4- carboxamide

CAS號	1197300-24-5
規(guī)格	5mg10mg	純度	98%
貨號	HY-14229	貨期	3天
品牌	Medchemexpress	庫存	需咨詢
規(guī)格	5mg10mg
純度	98%
貨號	HY-14229
貨期	3天
品牌	Medchemexpress
庫存	---
注意：請務必與賣家聯(lián)系核實單價庫存，以確保您的資金安全及交易順利。
參考價：￥2604.00 元/5mg

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貨號	品牌	純度	規(guī)格	參考價	貨期
HY-14229	Medchemexpress	98%	5mg10mg	￥2604.00元/5mg	3天

產品詳情

詳細信息(中文)：
TGR5 Receptor Agonist是TGR5(GPCR19)激動劑。

詳細信息(英文)：
產品描述：TGR5 Receptor AgonistTGR5 Receptor Agonist, a potent TGR5(GPCR19) agonist, showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5)._x000D_ IC50 value: 6.8 (pEC50, U2-OS cell assay); 7.5(pEC50, melanophore cell) [1]_x000D_ Target: TGR5_x000D_ TGR5 Receptor Agonist was profiled against more than 100 in-house and external 7TM, ion channel, enzyme, transporter, and nuclear hormone receptor selectivity assays, including FXR, another bile acid receptor, and showed significant response only in secretion of the pro-inflammatory cytokine TNFalpha (pIC50 = 6.8) in human primary monocytes following stimulation with LPS (lipopolysaccharide). In addition, TGR5 Receptor Agonist has good physicochemical properties and no measurable activity against three of the common cytochrome P450 (CYP450) isoforms (1A2, 2C9, and 2D6) or hERG dofetilide binding (pIC50

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物理化學性質
英文名	3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-1,2-oxazole-4- carboxamide
中文名	3-(2-氯苯基)-n-(4-氯苯基)-n,5-二甲基-4-異噁唑羧酰胺
CAS號	1197300-24-5	溶解性	---
分子量	361.22200	熔點	---
密度	---	沸點	---